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Scientists Explain Why Humans Seek Out Scary Experiences

  • University of Colorado Boulder researchers identified the interpeduncular nucleus as a brain circuit managing freeze-and-flee responses, the study in Molecular Psychiatry reports.
  • In a 'mouse haunted house' maze, Elora Williams and Susanna Molas projected a predator-like visual looming stimulus for three consecutive days and tracked neural signals with fiber photometry.
  • On the first day, mice froze and fled as IPN activity spiked, by day three they habituated and IPN activity dropped, while optogenetics flipped fear behaviors regardless of exposure.
  • Authors say IPN disruptions could contribute to anxiety and PTSD, and this work challenges the amygdala-centric view by assigning fear regulation to the interpeduncular nucleus .
  • The discovery links to theories that horror serves as a threat simulation, advancing understanding of how horror and frightening entertainment promote psychological resilience and adaptive learning.
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A key circuit not only triggers solidification and escape reaction. It also pushes it down again as soon as you realize that there is no real danger

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fli.institute broke the news in on Saturday, October 30, 2021.
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