Safety Evaluation of Long-term Administration of Umbilical Mesenchymal Stem Cell-Derived Extracellular Vesicles

Safety Evaluation of Long-term Administration of Umbilical Mesenchymal Stem Cell-Derived Extracellular Vesicles

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) hold significant therapeutic promise in regenerative medicine; however, their long-term safety profile remains inadequately characterized for clinical translation. In this study, human umbilical cord MSC-derived EVs (hucMSC-EVs) we...

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs - Pharma Excipients

Abstract The safety of repeated microarray patch (MAP) application is crucial for its development as an innovative drug delivery platform. This study is the first to assess the safety of repeated applications of hydrogel-forming, dissolving, and implantable MAPs over four weeks using miniature pigs, an industry-standard dermatological model with human-like skin structure and physiological responses. Uniform MAPs are successfully manufactured, wi…