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Experts Warn Vaping Alters Genes, Fruit Flavors Do Most Damage
Researchers found flavored vapes and newer devices drove most gene activity changes, with fruit and multiple flavors showing the strongest effects.
A study published in Frontiers in Oncology reveals that vapers show altered activity in 3,124 genes compared to non-users, based on analysis of 83 participants from the University of Southern California .
While 28.8% of gene changes relate to usage frequency, a much greater portion—66.6%—stems from flavor and device type, according to study senior author Ahmad Besaratinia.
Among vapers, those using fruit or multiple flavors showed the strongest changes, with multiple flavors accounting for 64.3% of affected genes and fruit flavors for 31%. Advanced refillable devices, often called "mods," produced the most consistent gene regulation shifts.
These findings provide critical data for the Food and Drug Administration as regulators evaluate flavored e-cigarette products. Besaratinia recommends adopting a granular approach to scrutinize specific product characteristics.
Researchers are now conducting follow-up studies on chemicals used in vaping liquid to identify compounds driving molecular shifts. This work aims to help policymakers instruct manufacturers to reduce or eliminate toxic additives.