US EditionResearchers unravel the genetic contributions to familial Alzheimer's disease development
- Researchers at VIB-KU Leuven led by Prof. Lucía Chávez Gutiérrez unraveled how specific genetic mutations predict familial Alzheimer's disease onset.
- Their study analyzed mutations in PSEN1, PSEN2, and APP genes, linking mutation effects to age of disease onset and predicting onset delays by up to five years.
- This genetic work complements advances like the recent EMA approval of Lecanemab, a drug targeting amyloid-beta proteins to slow Alzheimer's progression.
- Studies also suggest vaccines, including shingles, reduce Alzheimer's risk by about 20% over seven years, and improving lifestyle factors can prevent nearly half of dementia cases.
- These findings support personalized treatment and prevention strategies, highlighting ongoing research to improve early diagnosis and develop new therapies for Alzheimer's disease.
13 Articles
13 Articles
Researchers unravel the genetic contributions to familial Alzheimer's disease development
A group of researchers in the lab of Prof. Lucía Chávez Gutiérrez (VIB-KU Leuven) have unraveled the genetic contributions to familial Alzheimer's Disease development and revealed how specific mutations act as a clock to predict the disease age of onset.
Report shows effects of Alzheimer’s in KY, the disease ‘you can’t see’ • Kentucky Lantern
Reda and Joe Harrison (Photo provided)Before Reda Harrison was diagnosed with Alzheimer’s disease, she worked 10-hour days as a surgery coordinator in Lexington. Always “an organized person,” Harrison “knew something was wrong” when, in 2018, she started feeling confused and lost at work. Waking at 5 a.m. for work, the Nicholasville woman, 65, said she eventually “made an index card to tell me every step I had to take every morning: brush my t…
Alabama's HudsonAlpha launches pilot project to study Alzheimer’s disease - Alabama News Center
HudsonAlpha Institute for Biotechnology, in collaboration with Phenome Health and the Buck Institute for Research on Aging, has launched a pilot study to explore how genetics and lifestyle influence a person’s risk of developing Alzheimer’s disease and related dementias. The study, called HOPE AD (Healthy Outcomes through Phenomic Explorations for Alzheimer’s Disease), is enrolling participants at the Smith Family Clinic for Genomic Medicine in …
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