US EditionReassessing Antidepressant Efficacy: A Meta-Analysis of Control Group Outcomes in SSRI, Psilocybin, and Esketamine Trials
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Reassessing Antidepressant Efficacy: A Meta-Analysis of Control Group Outcomes in SSRI, Psilocybin, and Esketamine Trials
A meta-analysis showed that control group outcomes in psilocybin trials for depression were significantly weaker than those in selective serotonin reuptake inhibitor (SSRI) and esketamine trials, suggesting that psilocybin’s large observed treatment effects may be inflated by methodological factors such as functional unblinding and expectancy bias.
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