Data Mining Uncovers Treasure-Trove of Previously 'Untouchable' Proteins for Drug Development

Scientists just found 200+ hidden proteins that may drive Alzheimer’s

A surprising new study has uncovered over 200 misfolded proteins in the brains of aging rats with cognitive decline, beyond the infamous amyloid and tau plaques long blamed for Alzheimer’s. These shape-shifting proteins don’t clump into visible plaques, making them harder to detect but potentially just as harmful. Scientists believe these “stealth” molecules could evade the brain’s cleanup systems and quietly impair memory and brain function. Th…

Data mining uncovers treasure-trove of previously 'untouchable' proteins for drug development

Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By linking a disease-related protein to one that triggers a cell's demolition and recycling pathways, pharmaceutical researchers have been able to develop novel therapies for otherwise drug-resistant diseases.

Dementia: Long-Term Study Reveals New Findings - Medical Frontiers | NHK WORLD-JAPAN

Hisayama Town in southern Japan has held health checkups since the 1960s. Using this data, Kyushu University identified two markers linked to early dementia. We present the latest findings.

Rat study reveals more misfolded proteins potentially causing dementia

A new study from John Hopkins University in the US has identified hundreds of misfolded proteins that may be contributing to Alzheimer’s and cognitive decline. Traditionally, research into Alzheimer’s has been dominated by 2 amyloids, A-beta and tau. These amyloids, or clumps of misfolded proteins, can kill brain cells and cause cognitive decline.  Graphic rendition of a proteasome, which breaks down misfolded and damaged proteins inside a cell.…

More misfolded proteins than previously known may contribute to Alzheimer's and dementia

For decades, the story of Alzheimer's research has been dominated by a battle between A-beta and tau amyloids, both of which can kill neurons and impact the brain's ability to function. A new study suggests, however, that these sticky brain plaques may not be operating alone.