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Two-week radiotherapy proven as safe and effective as eight-week course for prostate cancer: 10-year follow-up

  • Swedish researchers shared 10-year findings from the HYPO-RT-PC trial at ESTRO 2025, demonstrating that a condensed two-and-a-half-week radiotherapy regimen matches the safety and efficacy of the conventional eight-week treatment for localized prostate cancer.
  • This large Phase III study included a cohort of 1,200 patients diagnosed with localized prostate cancer at intermediate to high risk, aiming to evaluate shorter radiotherapy regimens amid concerns about traditional treatment duration and healthcare resource demands.
  • Failure-Free survival was 72% in the short-course group and 65% in the standard group, with similar urinary and bowel side effects reported in both groups after a decade.
  • Associate Professor Per Nilsson highlighted that the extended follow-up results support earlier five-year data, demonstrating that administering fewer higher doses within a shorter timeframe achieves similarly effective and safe cancer control.
  • The findings suggest shorter radiotherapy schedules could reduce patient disruption and healthcare costs without compromising effectiveness, potentially changing prostate cancer treatment practices.
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Diario La Verdad broke the news in on Wednesday, April 30, 2025.
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