Preparation and Characterization of Diclofenac Sodium-Purolite A430MR Complexes for Taste Masking - Pharma Excipients
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Preparation and Characterization of Diclofenac Sodium-Purolite A430MR Complexes for Taste Masking - Pharma Excipients
Abstract The taste of a drug impacts the compliance of patients for oral administration. In this study, the bitter taste of diclofenac sodium (DS) was masked with purolite A430MR through ion exchange. The DS-A430MR complexes (DACs) were prepared at a 1:1 (w/w) drug to resin through a simple aqueous binding process. The key factors affecting release behaviors were identified by optimized experiments. The taste masking effect of the DACs was evalu…
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