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Early Menopause Linked to Higher Lifetime Heart Disease Risk

Women experiencing menopause before 40 have a 40% higher lifetime risk of coronary heart disease, with Black women three times more likely to face premature menopause, researchers say.

  • On Wednesday, a study published in JAMA Cardiology found that premature menopause increases lifetime coronary heart disease risk by 40%, based on data from 10,036 women analyzed by Northwestern University researchers.
  • Premature menopause was three times more common among Black women than white women , with study authors suggesting the disparity stems from genetic, biological, and environmental factors rather than inherent biological differences alone.
  • Dr. Priya Freaney, a cardiologist at Northwestern Medicine Bluhm Cardiovascular Institute, explained that declining estrogen triggers cholesterol and blood pressure increases, causing arteries to stiffen and accelerate blockages.
  • Clinicians should routinely assess menopause history to identify high-risk individuals early, with Freaney stating, "The vast majority of heart disease is preventable, but people need to know that they're at risk early."
  • Experts emphasize that menopause is "not just a reproductive issue; it's also a heart health issue," and lifestyle changes like exercise and smoking cessation can help mitigate risks, though researchers note further study is needed to understand underlying mechanisms.
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The causes of premature menopause are not fully understood and are likely related to genetic, biological and environmental factors.

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MedPage Today broke the news in New York, United States on Wednesday, March 18, 2026.
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