Cas9 Ancestor Engineered Into a Compact Genome Editing Tool

Cas9 ancestor engineered into a compact genome editing tool

Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. The engineered protein, called NovaIscB, can be adapted to make precise changes to the genetic code, modulate the activity of specific genes, or carry out other editing tasks. Because its small size simplifies delivery to cells, NovaIscB's develop…

Powerful CRISPR system inserts whole gene into human DNA

‘Directed’ evolution in the laboratory creates an editing tool that outperforms classic CRISPR systems. ‘Directed’ evolution in the laboratory creates an editing tool that outperforms classic CRISPR systems.

Revolutionary Gene Editing Tool Achieves Unprecedented Precision

In a groundbreaking development in the field of gene therapy, researchers have unveiled the evoCAST gene editor, an innovative tool designed to enhance the precision and effectiveness of gene editing. This revolutionary system, being worked on in the laboratories of Samuel Sternberg at Columbia University and David Liu at the Broad Institute of MIT and Harvard, promises to overcome a significant challenge in genetic medicine: the ability to inse…

Evolved gene editor inserts entire genes in human cells

Evolved gene editor inserts entire genes in human cells By Allessandra DiCorato May 15, 2025 Breadcrumb Home Evolved gene editor inserts entire genes in human cells The new system is the first to use a DNA-mobilizing enzyme called a CRISPR-associated transposase to make targeted gene-sized edits at therapeutically useful levels in human cells. By Allessandra DiCorato May 15, 2025 Credit: Susanna Hamilton, Broad Communications Related news…