US EditionPoorly water-soluble APIs in fixed-dose combinations: development, challenges, and opportunities in manufacturing techniques - Pharma Excipients
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Poorly water-soluble APIs in fixed-dose combinations: development, challenges, and opportunities in manufacturing techniques - Pharma Excipients
Abstract The incorporation of poorly soluble active ingredients, which make up the majority of the molecules in development, into fixed-dose combination (FDC) products can be an efficient method to improve the pharmacokinetic properties of these compounds, as well as reduce the side effects and enhance patient compliance by reducing the pill burden. The complexity of formulation development is given by the potential antagonistic interactions pre…
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