Polyclonal expansion of functional tumor-reactive lymphocyte infiltrating glioblastoma for personalized cell therapy

Future Leader Spotlight: Dr Ángel Álvarez-Prado

Ángel will lead the Translational Cancer Immunogenics group at the Luxembourg Institute of Health. His research group studies how changes in DNA affect the immune system’s fight against cancer and how this impacts the success of treatments. The Future Leaders grant programme Our Future Leaders grant programme was created to empower outstanding academic and clinical researchers at the start of their careers, helping them establish themselves as l…

Polyclonal expansion of functional tumor-reactive lymphocyte infiltrating glioblastoma for personalized cell therapy

Tumor-infiltrating lymphocyte (TIL)-therapy has received FDA approval for the treatment of advanced melanoma and shows potential for broader applications in solid tumors, including glioblastoma. In this study, tumor-reactive TILs (tr-TILs) were isolated and enriched for CD137 expression from cavi...