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PLGA/TPGS nanoparticles for docetaxel delivery: the pegylation effect on nanoparticle physicochemical properties and uptake and cytotoxicity in prostate cancer cells - Pharma Excipients

Summary by Pharma Excipients
Abstract Prostate cancer is the most common malignancy in men worldwide and docetaxel (DTX) is the treatment of choice. However, both the drug and formulation excipients for drug solubilization can cause side effects. In this context, the development of polymeric nanoparticles offers advantages to improve drug delivery and reduce toxicity. In the present work, factorial design was used to evaluate the effect of the amount of poly(L-lactide-co-g…
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PLGA/TPGS nanoparticles for docetaxel delivery: the pegylation effect on nanoparticle physicochemical properties and uptake and cytotoxicity in prostate cancer cells - Pharma Excipients

Abstract Prostate cancer is the most common malignancy in men worldwide and docetaxel (DTX) is the treatment of choice. However, both the drug and formulation excipients for drug solubilization can cause side effects. In this context, the development of polymeric nanoparticles offers advantages to improve drug delivery and reduce toxicity. In the present work, factorial design was used to evaluate the effect of the amount of poly(L-lactide-co-g…

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Pharma Excipients broke the news in on Tuesday, April 1, 2025.
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