Pitt research points to solution for growing problem of bacteria resistance

Over-activation of a nonessential bacterial protease DegP as an antibiotic strategy

Rising antibiotic resistance urgently begs for novel targets and strategies for antibiotic discovery. Here, we report that over-activation of the periplasmic DegP protease, a member of the highly conserved HtrA family, can be a viable strategy for antibiotic development. We demonstrate that tripodal peptidyl compounds that mimic DegP-activating lipoprotein variants allosterically activate DegP and inhibit the growth of an Escherichia coli strain…

Pitt research points to solution for growing problem of bacteria resistance

Antibiotic resistance a key global threat to public health, directly responsible for 1.27 million deaths in 2019 and associated with 4 million others per the WHO.

New class of antibiotics discovered 30 years after the last

source A new class of antibiotics has been identified by a group of researchers from American and Canadian universities. It is an extremely powerful and effective molecule… by davideownzall