Identification of Prolyl Isomerase Pin1 as a Novel Positive Regulator of YAP/TAZ in Breast Cancer Cells

Researchers aim to adapt metastatic breast cancer therapy as tumors change

Yale researchers are part of a collaboration developing an “evolutionary” approach to treating metastatic breast cancer, in which therapy choices are adapted as patients’ cancer changes.

Identification of Prolyl isomerase Pin1 as a novel positive regulator of YAP/TAZ in breast cancer cells

The Hippo signalling pathway plays very important roles in tumorigenesis, metastasis, organ size control, and drug resistance. Although, it has been shown that the two major components of Hippo pathway, YAP and TAZ, play very crucial role in tumorigenesis and drug resistance, the exact molecular mechanisms are still unknown. Recently, we have shown that the prolyl isomerase Pin1 regulates the activity of Hippo pathway through interaction with Hi…

PIN1 Expression in Childhood Celiac Disease: Insights into Inflammation and Cancer Risk

Objectives The PIN1 gene has been identified as an isomerase associated with various malignancies and is believed to play a role in inflammatory processes. In this study, we examined the relationship between PIN1 gene expression and disease severity, as well as the potential risk of m...