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Cancer jab can eradicate entire tumours in patients, trial shows
In a 102-patient trial, amivantamab shrank or erased tumours in 43 patients and cleared them completely in 15.
On Sunday, researchers will present results at the American Society of Clinical Oncology meeting in Chicago showing amivantamab shrank or eradicated head and neck tumours in 43 of 102 patients, including 15 complete responses.
This triple-action jab blocks EGFR and MET pathways while activating the immune system, targeting HPV-negative head and neck cancers that typically resist standard chemotherapy and immunotherapy.
Carl Walsh joined the OrigAMI-4 trial at the Royal Marsden in July 2025, reporting his diet and speech returned to normal; most patients experienced mild side-effects, with fewer than one in 10 stopping treatment.
Describing the responses as 'unprecedented,' Kevin Harrington, professor in biological cancer therapies at the Institute of Cancer Research, noted this represents a significant step forward for thousands of patients annually.
Johnson is evaluating amivantamab in about 60 clinical trials across multiple cancer types, with similar results reported in lung cancer, signaling potential to extend beyond current head and neck applications.