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Oprah Gets Honest About Her Weight Loss in Personal Chat with Best Friend Gayle King

Oprah Winfrey calls obesity a chronic disease and credits GLP-1 medications with reducing her urge to overeat and improving her wellbeing, based on her book and interviews.

Summary by Hello!
Oprah Winfrey has lost 40 to 50 pounds with a GLP-1 weight loss medication. But before then, she was riddled with shame about the public scrutiny her weight faced.

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Business Insider broke the news in United States on Tuesday, January 13, 2026.
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