Astrocytes Influence Metabolism and Cognitive Function in Obesity

Aquaporin-4 inhibition alters cerebral glucose dynamics predominantly in obese animals: an MRI study

Glucose uptake and metabolism are linked to microvascular blood flow and cellular swelling events, which are altered during obesity and can be quantified using magnetic resonance imaging (MRI). Aquaporin-4 (AQP4), the most abundant water-transporting transmembrane protein in the central nervous system, facilitates glucose transport and metabolism-derived water influx. However, its significance and regulatory capacity remain largely unknown. To b…

Astrocytes influence metabolism and cognitive function in obesity

Fatty diets and obesity affect the structure and function of astrocytes, the star-shaped brain cells located in the striatum, a brain region involved in the perception of pleasure generated by food consumption.

Fatty diets linked to brain cell changes, but astrocyte manipulation can reverse obesity effects

Fatty diets and obesity affect the structure and function of astrocytes, the star-shaped brain cells located in the striatum, a brain region involved in the perception of pleasure generated by food consumption. What is even more surprising is that by manipulating these astrocytes in vivo in mice, it can influence metabolism and correct certain cognitive changes associated with obesity (ability to relearn a task, for example).

Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia

Obesity-Related Cognitive Deficits Improved Through Astrocyte Modulation

Fatty diets and obesity affect the structure and function of astrocytes, the star-shaped brain cells located in the striatum, a brain region involved in the perception of pleasure generated by food consumption.

Obesity: the unexpected role of astrocytes