Novel monoclonal antibodies show promise in preventing severe mpox disease

Novel monoclonal antibodies show promise in preventing severe mpox disease

A team from the Microbiology Department at the Icahn School of Medicine at Mount Sinai has discovered three powerful monoclonal antibodies from a person who had previously been infected with mpox (formerly known as monkeypox).

Mpox Death in Mice Prevented by Antibodies Targeting A35 Protein

The global resurgence of mpox, along with its evolving epidemiology and sustained human-to-human transmission, highlights the need to investigate the human antibody response to key monkeypox virus (MPXV) antigens to better guide public health and vaccination strategies. In a new study published in Cell titled, “Human monoclonal antibodies targeting A35 protect from death caused by mpox,” researchers from Icahn School of Medicine at Mount Sinai h…