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No link between Tylenol use in pregnancy and autism or ADHD, new study finds

A review of 43 studies including sibling comparisons found no evidence linking acetaminophen use in pregnancy to autism, ADHD, or intellectual disability, supporting current medical guidance.

  • Published Friday, a major meta-analysis pooling about 60 studies found that acetaminophen taken as directed in pregnancy is not linked to autism, ADHD or intellectual disability.
  • Earlier studies showed mixed results, leaving pregnant people unsure about acetaminophen safety as study authors noted symptoms like fever, infection, pain and inflammation may confound links to fetal brain development.
  • Focusing on sibling-comparison designs, the review emphasized studies comparing siblings with and without prenatal acetaminophen exposure and included follow-up longer than five years.
  • Study authors and clinicians said pregnant women should feel reassured that acetaminophen remains the recommended first-line option for pain or fever in pregnancy when used as directed, and ACOG advises the lowest effective dose for the shortest time with care for persistent or high fever.
  • Voices outside the study cautioned or criticized, including an HHS official who said it "does not resolve an important public health question; it sidesteps it," while President Donald Trump and the FDA debated acetaminophen's safety and Kenvue defended Tylenol.
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Taking paracetamol during pregnancy is safe and there is no evidence it increases the risk of autism, ADHD and developmental problems in children, say experts behind a major new study. Pregnant women “should feel reassured” by the findings, they say, which contradict claims by US President Donald Trump last year that paracetamol “is not good” and that pregnant women should “fight with all their might” not to take it. His views were criticised at…

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Science Daily broke the news in United States on Friday, January 16, 2026.
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