New strategy prevents toxic protein clumps that drive ALS: Study

New strategy prevents toxic protein clumps that drive ALS: Study

Targeting a specific part of the TDP-43 protein can prevent toxic protein clumping that drives amyotrophic lateral sclerosis (ALS) without disrupting the protein’s normal function, a new study shows. “Current [U.S.-approved] treatments for ALS provide only modest benefits. There is an urgent need for a real breakthrough,” Xinglong Wang, PhD, the study’s senior author and a professor at the University of Arizona’s R. Ken Coit College of Pharmacy,…