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Long-Term Safety and Effectiveness of mRNA-1273 Vaccine in Adults: COVE Trial Open-Label and Booster Phases

Summary by Nature
Primary vaccination with mRNA-1273 (100-µg) was safe and efficacious at preventing coronavirus disease 2019 (COVID-19) in the previously reported, blinded Part A of the phase 3 Coronavirus Efficacy (COVE; NCT04470427) trial in adults (≥18 years) across 99 U.S. sites. The open-label (Parts B and C) primary objectives were evaluation of long-term safety and effectiveness of primary vaccination plus a 50-µg booster dose; immunogenicity was a second…

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Medical Xpress broke the news in on Tuesday, June 3, 2025.
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