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Lithium Deficiency Linked to Alzheimer's Onset, Orotate Restores Memory in Mice

UNITED STATES, AUG 6 – Researchers found lithium deficiency accelerates Alzheimer’s pathology and that low-dose lithium orotate reverses memory loss in mice, potentially benefiting 6.7 million affected adults in the U.S.

  • Lithium deficiency may be linked to Alzheimer’s disease, according to research from Harvard University.
  • The team found that lithium orotate can prevent memory loss in mice and does not bind to amyloid plaques.
  • Experts stress the importance of clinical trials to explore lithium orotate's effects on humans, recognizing the study's findings as significant and novel.
  • The Harvard team successfully restored memory function in mice by reintroducing lithium orotate, a less toxic compound, into their diet.
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As more and more people struggle with dementia every year, scientists have discovered that lithium slows down memory loss and even restores it.

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Nature broke the news in United Kingdom on Wednesday, August 6, 2025.
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