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New drug delivery method promises months-long effects with fewer injections

Summary by Phys.org

MIT engineers have devised a new way to deliver certain drugs in higher doses with less pain, by injecting them as a suspension of tiny crystals. Once under the skin, the crystals assemble into a drug "depot" that could last for months or years, eliminating the need for frequent drug injections.

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Sci Tech Daily

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Cheaper and More Effective: New MIT Breakthrough Could Improve Popular Weight Loss Drugs Such As Ozempic

MIT scientists have created a method to “paint” GLP-1 drugs onto antibodies inside the body, achieving longer-lasting effects with smaller doses. Glucagon-like peptide-1 (GLP-1) receptor agonists are peptide-based drugs used to treat diabetes and support weight loss. However, limited availability and high costs have made it challenging for many patients to begin or maintain therapy. [...]

3 days ago

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Nature

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Self-aggregating long-acting injectable microcrystals

Injectable drug depots have transformed our capacity to enhance medication adherence through dose simplification. Central to patient adoption of injectables is the acceptability of needle injections, with needle gauge as a key factor informing patient discomfort. Maximizing drug loading in injectables supports longer drug release while reducing injection volume and discomfort. Here, to address these requirements, we developed self-aggregating lo…

4 days ago·United Kingdom

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Irish Examiner

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Scientists develop injection for long-lasting contraceptive implant

Approach could herald new way of delivering drugs beyond birth control — such as for HIV, TB, schizophrenia, chronic pain, or metabolic disease — over long periods of time

4 days ago·Ireland

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WBBJ TV

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FDA approves new immunotherapy-based treatment option

JACKSON, Tenn. — Patients with certain cancers now have a new, faster method of receiving treatment. The FDA recently approved an immunotherapy-based treatment option that can be administered by under the skin, injection. This new method can deliver consistent efficacy and comparable safety as the IV treatment with faster delivery. This has significant impact in terms of options for patients and caregivers. “There’s increased flexibility now wit…

5 days ago

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Science Daily

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Engineers develop a better way to deliver long-lasting drugs

Engineers devised a way to deliver drugs such as contraceptives by injecting them as suspended crystals. Once under the skin, the crystals assemble into a drug depot that can last for months or years, eliminating the need for frequent injections.

5 days ago·United States

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