Single-Cell Atlas of Endothelial and Mural Cells across Primary and Metastatic Brain Tumors

Single-Cell Atlas of Endothelial and Mural Cells across Primary and Metastatic Brain Tumors

Scientists analyzed the two major blood-brain barrier cell types, endothelial and mural cells, across non-tumor brain tissue, isocitrate dehydrogenase (IDH) mutant low-grade gliomas, IDH wild-type high-grade glioblastomas, and brain metastases from various primary tumors. [Immunity] Full ArticleGraphical Abstract

New approach for T-cell immunotherapy against malignant brain tumors - German Cancer Research CenterLogo des Deutschen KrebsforschungszentrumsLogo des Deutschen KrebsforschungszentrumLogo der Deutschen Zentren der GesundheitsforschungLogo des Helmholtzins

Cellular immunotherapies have proven to be very successful in the treatment of various forms of blood cancer – but have so far failed when used on solid tumors. This is particularly true for glioblastomas, aggressive brain tumors that are additionally protected from the invasion of therapeutic cells by the blood-brain barrier and are therefore extremely difficult to treat.In order for immune cells to identify the cancer, suitable target structure