Study Reveals a Disease-Relevant Role for Tanycytes in Neurodegeneration

Study reveals a disease-relevant role for tanycytes in neurodegeneration

Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer's disease. In a paper publishing March 5 in the Cell Press journal Cell Press Blue, researchers report a previously unknown mechanism that appears to enable the build-up of tau.

Scientists Discover Hidden Brain Cells That Remove Toxic Alzheimer’s Protein

Scientists have identified damaged brain “cleanup” cells called tanycytes as a possible reason toxic tau builds up in Alzheimer’s disease. A buildup of the protein tau in the brain is a defining feature of Alzheimer’s disease. In a study published today (March 5) in the Cell Press journal Cell Press Blue, scientists describe a newly [...]

Mysterious brain cells clear proteins that contribute to Alzheimer’s disease

When specialized cells called tanycytes stop working, disease-causing tau proteins build up in the brain. When specialized cells called tanycytes stop working, disease-causing tau proteins build up in the brain.

Degenerating Tanycytes Disrupt Tau Removal, Shaping Alzheimer’s Progression

Tau‑clearing cells in the brain may offer new clues to slowing Alzheimer’s disease progression, according to a study titled “Tanycytic degeneration impairs tau clearance and contributes to Alzheimer’s disease pathology,” from Kyoto University and INSERM, published in Cell Press Blue. The work identifies a previously unrecognized mechanism by which the tau protein accumulates in the brain—a hallmark of Alzheimer’s pathology—and points to a specia…

Alzheimer's: new cells involved in the onset and progression of the disease - Health Care Today

An Inserm study reveals a close link between the abnormal accumulation of the Tau protein in the brains of Alzheimer’s patients and the role of tanycytes, cells known to ensure essential exchanges between the brain and the rest of the body. The results published in the journal Cell Press Blue show the involvement of these cells in the transport of the Tau protein and their importance in the pathophysiology of Alzheimer’s disease. Tanycytes could…

Little-Known Cells May Be Key to Clearing Alzheimer’s Proteins

New research reveals that specialized brain cells called tanycytes are responsible for clearing toxic Alzheimer’s proteins—and when they fail, the disease takes hold.