US EditionAPOE Gene: A Major Driver in Alzheimer's Disease
UCL-led research estimates 72–93% of Alzheimer's and about 45% of dementia cases are linked to APOE ε3 and ε4 variants, highlighting a key target for drug development.
- Recently, University College London researchers found APOE gene ε3 and ε4 variants explain 72 to 93% of Alzheimer's cases and approximately 45% of all dementia cases in a study published in npj Dementia.
- Pooling datasets including UK Biobank and FinnGen , the team analyzed over 450,000 participants from four large studies.
- Autopsy-Confirmed ADGC cohort showed 92.7% of Alzheimer's cases attributable to APOE3 and APOE4, and researchers found APOE3 contributes substantially to risk.
- Researchers urged prioritising APOE for mechanistic study and drug discovery, noting few current trials target APOE directly though LX1001 gene therapy recently showed promise in a phase I/II trial.
- Yet, authors cautioned that sample bias toward people of European ancestry and clinical misclassification limit findings, while Dr Dylan Williams highlighted gene-editing advances with "great, and probably under-appreciated, potential" for Alzheimer's interventions.
11 Articles
11 Articles
MedPage Today
Anti-Aging, Acupuncture and Health NewsAlzheimer's Risk May Be Driven by a Single Gene
(MedPage Today) -- Most Alzheimer's disease and nearly half of all dementia was associated with variations in the APOE gene, a study of 470,000 older adults suggested. In Alzheimer's disease, APOE3 and APOE4 were tied to 71.5% to 92.7% of cases...
Nearly 90% of Alzheimer’s cases linked to a single gene
Large-scale UK Biobank research suggests that variations in the APOE gene, linked to up to 90% of Alzheimer’s cases, are reshaping the scientific understanding of genetic risk and highlighting APOE as the focal point for future research New analysis of UK Biobank data supports APOE as the central genetic factor in Alzheimer’s risk. The study finds that even the common ε3 variant increases risk compared to the protective ε2, underscoring the need…
APOE Gene May Be Responsible for Most Alzheimer's Disease
Researchers based at University College London claim that the ε3 and ε4 variants of the APOE gene are responsible for most cases of Alzheimer’s disease. As reported in npj Dementia, an analysis using individuals with two copies of the protective ε2 variant as a comparator, 71–93% of Alzheimer’s and cerebral amyloidosis was attributable to ε3 and ε4 and around 44% of dementia. “When we consider the contributions of ε3 and ε4, we can see that APOE…
Coverage Details
Bias Distribution
- 50% of the sources lean Left, 50% of the sources are Center
Factuality
To view factuality data please Upgrade to Premium
