Mitochondrial rewiring may explain why orthoflaviviruses harm humans but persist in mosquitoes

Mitochondrial rewiring may explain why orthoflaviviruses harm humans but persist in mosquitoes

Orthoflaviviruses reshape mitochondrial structure, metabolism, redox signaling, and quality control differently across human and mosquito models, helping explain their contrasting infection outcomes. The review highlights mitochondrial pathways that may support acute cellular damage in vertebrates but persistent, non-lethal infection in mosquitoes, pointing to potential antiviral targets.

Mitochondrial Evolution History Explains Why Body Attacks Its Own Cells

Mitochondria are often called the powerhouses of the cell. But their ancient origins may also make them drivers of inflammation.

Mitochondrial Dynamics in Orthoflavivirus Infection: Insights from Human and Mosquito Hosts

Mosquito-borne orthoflaviviruses alternate between vertebrates and mosquitoes, where they establish distinct infection outcomes. The authors discuss how mitochondrial dynamics and inter-organelle communication may shape orthoflavivirus replication and infection outcome. [npj Viruses] Abstract