MINFLUX nanoscopy enhanced with high-order vortex beams

MINFLUX nanoscopy enhanced with high-order vortex beams

Minimal photon fluxes (MINFLUX) nanoscopy has emerged as a transformative advancement in superresolution imaging, enabling unprecedented nanoscale observations across diverse biological scenarios. In this work, we propose, for the first time, that employing high-order vortex beams can significantly enhance the performance of MINFLUX, surpassing the limitations of the conventional MINFLUX using the first-order vortex beam. Our theoretical analysi…

MINFLUX Nanoscopy Boosted by High-Order Vortex Beams

In the relentless pursuit of pushing optical microscopy beyond traditional limits, a groundbreaking advancement has emerged that promises to revolutionize nanoscale imaging. Researchers XJ Tan and Z. Huang have recently unveiled a novel enhancement to MINFLUX nanoscopy, employing high-order vortex beams to significantly elevate imaging resolution and precision. Published in the prestigious journal Light: Science & Applications in 2025, this new …