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Migraine drug is first to tackle debilitating early symptoms

  • Peter Goadsby and colleagues published in 2025 a phase 3 trial showing ubrogepant reduces early migraine symptoms in 438 adults with migraine history.
  • The study addressed the lack of effective treatments for prodrome symptoms like light sensitivity, fatigue, and neck pain that precede migraine headaches.
  • Participants reported better focus within one hour of treatment, decreased sensitivity to light after two hours, and reductions in tiredness and neck discomfort after three hours when taking ubrogepant compared to placebo.
  • Goadsby noted that patients experienced improvements in non-pain symptoms prior to the onset of headache, although the difference from placebo remained modest, with effect sizes not exceeding 15 percentage points.
  • The findings suggest ubrogepant could treat the full migraine cascade by alleviating disabling premonitory symptoms, highlighting the clinical relevance of early intervention.
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Nature broke the news in United Kingdom on Monday, May 12, 2025.
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