Migraine drug is first to tackle debilitating early symptoms
- Peter Goadsby and colleagues published in 2025 a phase 3 trial showing ubrogepant reduces early migraine symptoms in 438 adults with migraine history.
- The study addressed the lack of effective treatments for prodrome symptoms like light sensitivity, fatigue, and neck pain that precede migraine headaches.
- Participants reported better focus within one hour of treatment, decreased sensitivity to light after two hours, and reductions in tiredness and neck discomfort after three hours when taking ubrogepant compared to placebo.
- Goadsby noted that patients experienced improvements in non-pain symptoms prior to the onset of headache, although the difference from placebo remained modest, with effect sizes not exceeding 15 percentage points.
- The findings suggest ubrogepant could treat the full migraine cascade by alleviating disabling premonitory symptoms, highlighting the clinical relevance of early intervention.
13 Articles
13 Articles
Well-known migraine drug also helps relieve pre-symptoms of the disease
Ubrogepant, currently used primarily to relieve headaches associated with migraine attacks, may also prevent and relieve debilitating migraine pre-symptoms such as fatigue and sensitivity to light, a recent clinical trial suggests. However, only about one in five people appear to benefit from the drug.
Migraine drug can also help with symptoms that occur before the actual headache begins
A drug to treat migraine, ubrogepant, is also found to reduce common non-headache symptoms that occur in the hours preceding a migraine headache, according to the results of a large phase three clinical trial published in Nature Medicine. The findings suggest that ubrogepant may be the first acute treatment for the symptoms that occur before migraine, which have a considerable impact on daily function.
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