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Metabolic Rewiring That Protects against Ferroptosis Underlies Resistance to CDK4/6 Inhibition in Prostate Cancer
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Metabolic Rewiring That Protects against Ferroptosis Underlies Resistance to CDK4/6 Inhibition in Prostate Cancer
The authors demonstrated that acquired resistance to the CDK4/6 inhibitor ribociclib in prostate cancer cells is driven by enhanced mitochondrial metabolic activity and increased dependence on fatty acid β-oxidation for energy production through the TCA cycle. [Cell Death & Disease] AbstractFull Article
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