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Merck bets on flu prevention with $9.2 billion deal for Cidara Therapeutics

Merck will pay $9.2 billion to acquire Cidara's long-acting antiviral CD388 and Cloudbreak platform to strengthen its infectious disease pipeline amid Keytruda patent expirations.

  • Merck will acquire San Diego-based Cidara Therapeutics for nearly $9.2 billion, paying $221.50 per share, with the deal announced Friday and expected to close in the first quarter of 2026.
  • Merck is seeking late-stage assets as Keytruda's revenue faces pressure, looking to diversify beyond Keytruda as its patents expire later this decade; last year, Cidara reacquired rights to the CD388 program after Janssen stepped away.
  • Cidara's lead candidate CD388, a drug-Fc conjugate and not a vaccine, met its Phase 2b goals with about 5,000 participants, showing significant prevention and safety, according to the companies said.
  • Investors reacted immediately, sending Cidara shares more than double Thursday's close as the stock had been climbing since the June Phase 2 report, and Merck has scheduled a Monday 8 a.m. investor call to discuss the deal.
  • An interim analysis in the first quarter of 2026 will assess trial size and possible enrollment beyond 6,000 participants planned, and if successful CD388 could offer season-long protection for older adults and immunocompromised people.
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biopharmadive.com broke the news in on Friday, November 14, 2025.
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