Mapping how influenza virus rewires human host cells
The method captured virus-host protein contacts inside intact cells and showed influenza A actively rewires entry pathways and nuclear compartments.
- Researchers at EMBL Hamburg and the Leibniz Research Institute for Molecular Pharmacology mapped how the influenza A virus rewires human host cells with unprecedented structural detail on virus-host protein interactions.
- Combining in-cell cross-linking mass spectrometry with AlphaFold-based structural modeling, the team captured protein interactions directly in intact cells, overcoming previous methods that required destroying cells.
- Hijacking host factors to process hemagglutinin through the cell's endoplasmic reticulum-Golgi system, the virus ensures this surface protein is correctly folded and modified for successful infection.
- Dissolution of paraspeckles—tiny nuclear organelles—occurs consistently across all tested cell lines during infection. First author Iuliia Kotova, PhD, said this phenomenon "might be a strategy" rather than a side effect.
- Jan Kosinski, group leader at EMBL Hamburg, noted the methodology could apply to pandemic-relevant viruses like H5N1 to identify targets for future pharmaceutical interventions.
12 Articles
12 Articles
The influenza A virus is able to reprogram the infected human cells, taking control of their molecular machinery to promote the production of new viral particles. A process known for some time to scientists, but which has now been observed for the first time in detail within live and intact cells. The discovery, [...] L'articolo Unveiled as the influenza virus "reprogramma" the infected cells. The study on Nature comes from Il Fatto Quotidiano.
Scientists capture flu viruses surfing into human cells in real time
Scientists have captured a never-before-seen, high-resolution look at influenza’s stealthy invasion of human cells, revealing that the cells aren’t just helpless victims. Using a groundbreaking imaging technique, researchers discovered that our cells actually reach out and “grab” the virus as it searches for the perfect entry point, surfing along the membrane.
Flu virus controls human cells and multiplyes in the Freepik body An international study led by scientists from the European Molecular Biology Laboratory (EMBL), Germany, mapped for the first time, in detail, how the influenza A virus takes control of human cells to multiply within the body. Every cell in the body has its own gear: internal plants that produce proteins, systems that transport these proteins to where they are needed and structure…
New Study Reveals How Flu Virus Hijacks Human Cells to Multiply
Get latest articles and stories on Health at LatestLY. Researchers at EMBL Hamburg and their collaborators have mapped, for the first time, how the influenza A virus directly rewires infected human cells by tracking virus-host protein interactions inside intact cells. Health News | New Study Reveals How Flu Virus Hijacks Human Cells to Multiply.
New study reveals how flu virus hijacks human cells to multiply - The Tribune
Researchers at EMBL Hamburg and their collaborators have mapped, for the first time, how the influenza A virus directly rewires infected human cells by tracking virus-host protein interactions inside intact cells.
Coverage Details
Bias Distribution
- 50% of the sources lean Right
Factuality
To view factuality data please Upgrade to Premium
