Mapping cross-reactive residues in the G-H loop of foot-and-mouth disease virus: insights for serotype-specific design

Mapping cross-reactive residues in the G-H loop of foot-and-mouth disease virus: insights for serotype-specific design

Mapping cross-reactive residues in the G-H loop of foot-and-mouth disease virus: insights for serotype-specific design Introduction: Foot-and-mouth disease virus (FMDV) has a hypervariable G-H loop region within the VP1 capsid protein. This structure is associated with virus neutralisation and contains the virus attachment motif (RGD) which binds to the cellular integrin receptor facilitating virus entry for all seven FMDV serotypes.Methods: Six…