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In total, 30 have been published by pirbright.ac.uk which Ground News has aggregated in the past 3 months.

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Top pirbright.ac.uk News

Influenza · Sonora

Avian Influenza Fear Sonora in Arizona

The slaughter of more than 5 million birds keeps producers concerned, said the holder of SAGARHPA, Célida López Cárdenas. Enrique Delgadillo/La Onda 99.5 FM and 1190 AM PHOENIX — At the recent summit of the Arizona-Mexico Commission, many issues were put on the table, among them, the situation that keeps Sonora producers on alert and busy keeping millions of birds healthy in order to prevent the spread of H5N1 avian influenza. Célida López Cárde…See the Story

Pirbright · Pirbright

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity Bats are reservoirs of emerging zoonotic viruses that may cause severe disease in humans and agricultural animals. However, it is poorly understood how bats can tolerate diverse viral infections. Here, we characterized type I interferon response pathways in kidney cell lines derived from two divergent bat species, Pteropus alecto and Eptesicus fus…Read Article

Vaccines

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate More efficacious vaccines are required to improve control of porcine reproductive and respiratory syndrome viruses (PRRSV). One strategy that has shown promise is the use of centralized antigens, generated from consensus sequence data. Here, we evaluated the consensus sequence approach to dev…Read Article

CRISPR chicken cell study boosts potential for vaccine development

Pirbright scientists create gene-edited chicken cells that produce much higher yields of influenza A and Newcastle disease virus – a key to improved vaccine production.CRISPR · Woking See the Story

Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges

Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges Since 2020, the clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 viruses have caused unprecedented outbreaks in wild birds and domestic poultry globally, resulting in significant ecological damage and economic losses due to the disease and enforced stamp-out control. In addition to the avian hosts, the H5N1 viruses have expanded their host…Influenza Read Article

Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX

Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX African swine fever virus originated in a wildlife cycle in East Africa and spread to domestic pigs. At least twenty-three genotypes are present in Africa whereas only genotypes I and II have spread to other continents. Vaccine development has been directed mainly to genotype II. The ability of genotype II v…Read Article

Nationwide Avian Flu Response Gains Momentum, Yet Urgent Action Remains Essential

The ongoing H5N1 avian flu outbreak has severely impacted U.S. poultry and dairy industries, prompting a $1 billion USDA response strategy that includes biosecurity, vaccination research, and innovation funding. With growing concern over viral mutations affecting humans and livestock, rapid, field-based diagnostic tools offer critical support in accelerating detection and containment efforts.Influenza · Paris See the Story

Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs

Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs Tissue-resident memory (TRM) T cells play an important role in protection against respiratory infection but whether this memory is maintained by long-lived or dividing cells remains controversial. To address the rate of division of lung TRM T cells, deuterium-enriched water was administered orally to young pigs to label dividi…Pirbright · Pirbright Read Article

Estimating population immunity to SARS-CoV-2 by random sampling from primary and secondary healthcare in Scotland, May 2024

Estimating population immunity to SARS-CoV-2 by random sampling from primary and secondary healthcare in Scotland, May 2024 Background: As the COVID-19 pandemic has ended, the global focus has shifted from "pandemic response" to "long-term management". With no ongoing nationwide serosurveillance studies, our understanding of the level of immunity in the general population has diminished. In this study, we screened random samples from a bioreposi…Pandemic · Glasgow Read Article

Investigating the RelA Gene's role in African Swine fever tolerance: a study of Indian pigs

Investigating the RelA Gene's role in African Swine fever tolerance: a study of Indian pigs African Swine Fever (ASF) is a highly contagious transboundary viral disease affecting domestic pigs worldwide, often resulting in nearly 100 % mortality due to the lack of effective vaccines. However, wild species such as warthogs (Phacochoerus sp.) and bush pigs (Potamochoerus sp.) do not exhibit clinical symptoms of the disease, previous studies showed…India · India Read Article

Regulatory mechanism of DNMT3A in interferon expression inhibition by Newcastle disease virus V protein

Regulatory mechanism of DNMT3A in interferon expression inhibition by Newcastle disease virus V protein Newcastle disease (ND), caused by the Newcastle disease virus (NDV) and characterised by rapid onset and high mortality rates, is a highly contagious disease in the poultry industry. Interferons (IFN) play a key role in host defence against NDV, however, the non-structural protein V of NDV can antagonise IFN to facilitate NDV immune escape. DN…Pirbright · Pirbright Read Article

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Top pirbright.ac.uk News

Avian Influenza Fear Sonora in Arizona

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate

CRISPR chicken cell study boosts potential for vaccine development

Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges

Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX

Nationwide Avian Flu Response Gains Momentum, Yet Urgent Action Remains Essential

Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs

Estimating population immunity to SARS-CoV-2 by random sampling from primary and secondary healthcare in Scotland, May 2024

Investigating the RelA Gene's role in African Swine fever tolerance: a study of Indian pigs

Regulatory mechanism of DNMT3A in interferon expression inhibition by Newcastle disease virus V protein

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