MAGIC: A powerful tool to understand the origin of cancer

MAGIC: A powerful tool to understand the origin of cancer

The human body relies on precise genetic instructions to function, and cancer begins when these instructions get scrambled.

Origins of chromosome instability unveiled by coupled imaging and genomics

Somatic chromosome instability results in widespread structural and numerical chromosomal abnormalities (CAs) during cancer evolution1–3. Although CAs have been linked to mitotic errors resulting in the emergence of nuclear atypia4–7, the underlying processes and rates of spontaneous CA formation in human cells are underexplored. Here we introduce machine-learning-assisted genomics and imaging convergence (MAGIC)—an autonomously operated platfor…

Like MAGIC: New AI Tool Reveals How Chromosomal Errors Arise, Offers Clues to Cancer’s Origins

A new artificial intelligence-powered platform developed at the European Molecular Biology Laboratory (EMBL) in Heidelberg is offering insight into how chromosomal abnormalities arise in cancer biology. The tool, called MAGIC (machine learning-assisted genomics and imaging convergence), was created by researchers in Jan Korbel’s group at EMBL Heidelberg and published in a new Nature paper. MAGIC is an autonomously operated platform that integrat…

MAGIC: AI-assisted laser tag illuminates cancer origins

Summary During cell division, chromosomal abnormalities – defects in chromosome number or structure – can occur, which can cause particularly aggressive forms of cancer. A new study has shed light on how chromosomal abnormalities arise in normal cells, the rates at which they do so, and how these rates are affected by various factors. To do this, the scientists developed a novel and versatile artificial intelligence (AI) tool called MAGIC, whi…