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Dietary Control of Peripheral Adipose Storage Capacity Through Membrane Lipid Remodelling

GREATER LONDON, ENGLAND, JUL 9 – Researchers analyzed over 170,000 fat cells from 70 people and found weight loss removes damaged cells and boosts lipid recycling linked to improved metabolism.

Summary by Nature
Genetic and dietary cues are known drivers of obesity, yet how they converge at the molecular level is incompletely understood. Here we show that PPARγ supports hypertrophic expansion of adipose tissue via transcriptional control of LPCAT3, an endoplasmic reticulum (ER)-resident O-acyltransferase that selectively enriches diet-derived omega-6 polyunsaturated fatty acids (n-6 PUFAs) in the membrane lipidome. In mice fed a high-fat diet, lowering …

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The research shows that, after a weight loss, there are alterations that do not recover at all. “You have to take the blame from the people,” sums up one expert

·Spain
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BarBend broke the news in on Wednesday, July 9, 2025.
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