HIV uses circular RNAs to evade immunity and boost replication

HIV uses circular RNAs to evade immunity and boost replication

In a groundbreaking discovery, researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine have identified a never-before-seen mechanism that enables the human immunodeficiency type 1 virus (HIV-1) to evade the body's natural defenses and use it to support its survival and replication.

'Loop'hole: HIV-1 hijacks human immune cells using circular RNAs

Researchers have identified a never-before-seen mechanism that enables HIV-1 to evade the body's natural defenses and use it to support its survival and replication. The 'loophole' is a biological process that involves circular RNAs and marks the first experimental evidence of HIV-1 generating them from an integrated retroviral genome. Findings point to a novel strategy the virus uses to survive, providing a new target in the fight against one o…

HIV-1's hidden weapon: Circular RNAs help virus outsmart the immune system

In an important discovery, researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine have identified a never-before-seen mechanism that enables the human immunodeficiency type 1 virus (HIV-1) to evade the body's natural defenses and use it to support its survival and replication.

Viral circRNAs Sponge Up Host miRNAs to Weaken Immune Response

In a significant breakthrough, researchers from Florida Atlantic University’s Charles E. Schmidt College of Medicine have uncovered a previously unknown mechanism that allows the human immunodeficiency type 1 virus (HIV-1) to evade the body’s natural defenses, thereby facilitating its survival and replication.

Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses

Simian immunodeficiency viruses (SIVs) comprise a large group of primate lentiviruses that endemically infect African monkeys. HIV-1 spilled over to humans from this viral reservoir, but the spillover did not occur directly from monkeys to humans. Instead, a key event was the introduction of SIVs into great apes, which then set the stage for infection of humans. Here, we investigate the role of the lentiviral entry receptor, CD4, in this key and…