US EditionStem cell therapy frees diabetics from insulin
- Vertex Pharmaceuticals presented phase 2 FORWARD study results on June 20-23, 2025, showing that 10 of 12 type 1 diabetes patients became insulin independent after receiving zimislecel in Chicago.
- The results followed more than 25 years of research, with patients receiving a portal vein infusion of stem cell-derived islet cells plus immunosuppressive drugs to prevent immune rejection.
- All 12 participants showed islet cell engraftment with C-peptide detected after infusion, maintained healthy glucose levels, avoided severe hypoglycemia, and 10 stopped insulin use after about six months.
- Michael Rickels expressed optimism that the results could lead to a groundbreaking therapy, while Marlon Pragnell highlighted stem cell treatment as a highly encouraging development that could significantly improve management of type 1 diabetes.
- The study’s success may lead to a regulatory submission next year and suggests a potential new treatment to restore insulin production and reduce hypoglycemia risks in type 1 diabetes patients.
13 Articles
13 Articles
Hartford Courant
k24.digitalPeople with severe diabetes are cured in small trial of new drug
A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of Type 1 diabetes. One year later, these 10 patients no longer need insulin. The other two patients need much lower doses. The experimental treatment, called zimislecel and made by Vertex Pharmaceuticals of Boston, involves stem cells that scientists prodded to turn into pancreatic islet cells, which regulate blood glucose levels. The n…
London woman off insulin for Type 1 diabetes after a single dose of experimental manufactured stem cells
Amanda Smith celebrates the day, August 1, nearly two years ago, when she stopped taking insulin to manage her type one diabetes, just a few months after getting a dose of experimental stem cells as part of a study.
People with Severe Type 1 Diabetes are Cured in Small Trial of New Drug
"A single infusion of a stem cell-based treatment may have cured 10 out of 12 people with the most severe form of Type 1 diabetes," reports the New York Times. "One year later, these 10 patients no longer need insulin. The other two patients need much lower doses." The experimental treatment, cal...
Diabetes Cure: New Drug Shows Promise – Archyde
Archyde Diabetes Breakthrough: Stem Cell Therapies Show Promise in Curing Severe Cases London, England – The landscape of diabetes treatment is undergoing a revolutionary shift. Recent clinical trials showcase remarkable success… You can read the full story here: Diabetes Cure: New Drug Shows Promise.
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