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Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

Summary by Nature
Heterochronic parabiosis (HPB) is known for its functional rejuvenation effects across several mouse tissues. However, its impact on biological age and long-term health is unknown. Here we performed extended (3-month) HPB, followed by a 2-month detachment period of anastomosed pairs. Old detached mice exhibited improved physiological parameters and lived longer than control isochronic mice. HPB drastically reduced the epigenetic age of blood and…

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Science-et-vie.com broke the news in on Monday, April 21, 2025.
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