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JCI HIV causes global B cell dysregulation and restricts HBV-specific B cell development in an incident HBV cohort
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JCI HIV causes global B cell dysregulation and restricts HBV-specific B cell development in an incident HBV cohort
BACKGROUND Functional B cell responses for both prevention and control of hepatitis B virus (HBV) infection remain poorly understood, including in the context of HBV/HIV coinfection.METHODS Here, we employed high-dimensional single-cell analysis to assess global and hepatitis B surface antigen–specific (HBsAg-specific) B cells in a longitudinal cohort of incident HBV from the Multicenter AIDS Cohort Study, with a subset of the cohort living with…
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