US EditionJCI Haptenization as the missing link between vasculitis and myeloperoxidase
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JCI Haptenization as the missing link between vasculitis and myeloperoxidase
A wide variety of medications can induce adverse immune events and autoimmune responses such as vasculitis. Mechanistically, small molecule drugs known as haptens bind and modify endogenous proteins, triggering such immune reactions. In this issue of the JCI, Xi and colleagues investigated the immunological mechanism of autoimmune vasculitis associated with hydralazine. Notably, hydralazine-based haptenization modified myeloperoxidase (MPO), ind…
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