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Investigation and rank-ordering of hydroxypropyl methylcellulose (HPMC) properties impacting controlled release performance (Part 2) – Exploring variation of HP substitution over broader range
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Investigation and rank-ordering of hydroxypropyl methylcellulose (HPMC) properties impacting controlled release performance (Part 2) – Exploring variation of HP substitution over broader range
Abstract Hydroxypropyl methylcellulose (HPMC) is commonly used to enable controlled release (CR) of an active pharmaceutical ingredient (API) from a hydrophilic matrix tablet. In the previous study, twenty commercial batches of HPMC 2208 (METHOCEL K4M) were investigated, and their functionality-related characteristics (FRCs) were rank ordered by their impacts on performance. HP substitution and 2% viscosity most impacted controlled release of pa…
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