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Human Antibodies Drive Breakthrough in Broad-Spectrum Snake Antivenom

  • Tim Friede, a man from Wisconsin, deliberately subjected himself to more than 200 venomous snakebites and over 850 immunizations over 18 years to build immunity against venom.
  • He began self-immunizing by injecting escalating doses of venom from 16 highly lethal snake species out of curiosity and to protect himself from potentially fatal bites.
  • Scientists from Centivax, including Peter Kwong of Columbia University, studied antibodies in Friede's blood and identified a cocktail that neutralizes venom from 19 snake species, aiming for broad-spectrum antivenom.
  • Glanville said three antibody components provided full protection against 13 species and partial protection for others, but the antivenom is still experimental and only tested in mice so far.
  • While Friede's antibodies could help develop new treatments, experts warn this is early research and advise against replicating his dangerous method, emphasizing the need for better accessible snakebite therapies worldwide.
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Nature broke the news in United Kingdom on Friday, May 2, 2025.
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