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High court clears way for clinical trial giving puberty blockers to children

The judge said the challenge was not arguable, and the trial will enroll about 220 children with strict consent and monitoring safeguards.

  • On Friday, Mr Justice Chamberlain dismissed a legal challenge to the PATHWAYS Trial, ruling that the High Court would not block the puberty blocker study from proceeding.
  • NHS England commissioned the PATHWAYS Trial to assess puberty blocker risks after Baroness Cass's 2024 review found evidence for the drugs "remarkably weak," though legal action had previously paused recruitment.
  • Researchers at KCL hope to recruit 226 children under 16 who have received "many months" of psychological support from NHS Gender Services, with strict monitoring of physical and mental health throughout.
  • Good Law Project solicitor Zoe Johannes called the ruling "a significant win for young trans people," while Keira Bell described it as a "tragedy" that ignores long-term harm concerns.
  • Recruitment for the trial begins today, August 1, 2026, for children aged 11 to 16, with the Health Research Authority maintaining that the study remains "carefully designed" to ensure participant safety.
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The Good Law Project broke the news on Friday, July 31, 2026.
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