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Universal antivenom within reach thanks to man bitten by snakes over 200 times – on purpose

  • Tim Friede, a US man, deliberately exposed himself to over 200 snakebites and hundreds of venom injections from 16 species over 18 years to develop immunity.
  • His self-immunization aimed to produce broadly neutralising antibodies, addressing the challenge that current antivenoms only target individual snake species.
  • Researchers, including Jacob Glanville and Peter Kwong, studied Friede's blood, identifying two broadly neutralising human antibodies combined with a molecule, varespladib, tested successfully in mice.
  • This combination showed protection against venom from 13 genetically diverse venomous snakes, which experts described as an "unparalleled" breadth of protection with potential for broad antivenom use.
  • Although human trials are years away, this research could lead to safer, near-universal antivenoms, improving treatment access in remote areas where snakebite deaths and injuries remain high.
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rnd.de broke the news in Germany on Friday, May 2, 2025.
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