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Hayden Panettiere’s Official Cause of Death Revealed After Investigation

The coroner said toxic effects of fentanyl, 4-ANPP, alprazolam, methocarbamol and quetiapine caused the 36-year-old actress’s death, which was ruled an accident.

  • On Tuesday, the Greenville County Coroner's Office confirmed that actor Hayden Panettiere's death resulted from the toxic effects of fentanyl, 4-ANPP, Alprazolam, Methocarbamol, and Quetiapine. The manner of death was officially ruled an accident.
  • Panettiere, 36, died on Aug 16 at a South Carolina apartment complex when Greenville police officers responded to a report of an unresponsive female at around 1:50 p.m. local time. An acquaintance had placed the 911 call.
  • Toxicology results identified the toxic effects of fentanyl, 4-ANPP, Alprazolam, Methocarbamol, and Quetiapine as the cause of death. An autopsy discovered no signs of trauma that would have contributed to her passing.
  • Greenville Police Department investigators found no signs of foul play, though the Drug Enforcement Administration is also investigating. Brian Hickerson, Panettiere's on-again, off-again boyfriend, was present at the apartment and showed authorities a bag of medication.
  • Known for starring as Claire Bennet on NBC's "Heroes" and Juliette Barnes on "Nashville," Panettiere detailed her struggles with addiction and postpartum depression in her memoir "This Is Me: A Reckoning." She is survived by her daughter, Kaya.
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Hayden Panettiere's Cause of Death Revealed

Hayden Panettiere's Aug. 16 death at 36 has been ruled an accident, with the cause determined to be toxic effects from the drugs fentanyl, 4-ANPP, Alprazolam, Methocarbamol, and Quetiapine.

·Universal City, United States
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TMZ broke the news in Burbank, United States on Tuesday, September 22, 2026.
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