Guiding excipient selection for physically stable Amorphous Solid Dispersions: A combined in-vitro in-silico approach - Pharma Excipients

Guiding excipient selection for physically stable Amorphous Solid Dispersions: A combined in-vitro in-silico approach - Pharma Excipients

Abstract Fast screening of amorphous solid dispersions (ASDs) is a need in the pharmaceutical industry. To support this, several emerging technologies have been developed ranging from in-silico prediction to miniaturized high-throughput experimentation. However, a notable challenge lies in the absence of comparative data. In the present work, a combination of a miniaturized screening of ASDs with calculation of activity coefficients using the co…