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‘Grey’s Anatomy’: Kelly McCreary Reacts to Maggie’s Big News, Amelia’s Choice & That Trip Down Memory Lane

The 450th episode honors Grey's Anatomy's legacy with a pilot scene recreation and explores hospital explosion fallout and evolving character dynamics.

  • On Thursday, Oct. 16, Richard Webber reprised his pilot reality-check speech to a new intern class in Episode 2202, the series' 450th hour on ABC.
  • As a tribute to its history, the episode paid homage to Grey's past using Meredith Grey's carousel metaphor and Ellis Grey 's return.
  • Amid the chaos, an explosion killed Dr. Monica Beltran and nearly killed Link, while a forklift rescue case led Bailey to name Ben the new chief resident.
  • Amelia Shepherd announced a sabbatical to process grief, while Maggie Pierce returned and revealed she is pregnant after choosing a donor.
  • Now in its 22nd season, Grey's Anatomy continues featuring Richard Webber, Bailey, and Meredith Grey as the original regulars, while Zoanne Clack wrote and Kevin McKidd directed the milestone episode.
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‘Grey’s Anatomy’: Kelly McCreary Reacts to Maggie’s Big News, Amelia’s Choice & That Trip Down Memory Lane

The actress also reflected on being part of the show's 450th episode milestone.

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Entertainment Weekly broke the news in United States on Thursday, October 16, 2025.
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