Dopamine Type-1 Receptor Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]NNC-112

Dopamine Type-1 Receptor Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]NNC-112

The dopamine type-1 receptor has been implicated in major depressive disorder (MDD) by clinical and preclinical evidence from neuroimaging, post mortem, and behavioral studies. To date, however, selective in vivo assessment of D1 receptors has been limited to the striatum in MDD samples manifesting anger attacks. We employed the PET radioligand, [11C]NNC-112, to selectively assess D1 receptor binding in extrastriatal and striatal regions in a mo…

Ketamine treatment may now last months instead of weeks

Major breakthrough in depression treatment as scientists extend ketamine effects from 1 week to 2 months with single dose.

Novel Agent for Major Depression Moves to Phase III, Even With Setback

(MedPage Today) -- Despite missing the primary endpoint, the novel KV7 potassium channel opener azetukalner showed benefit in major depressive disorder (MDD) in the phase II, proof-of-concept, randomized X-NOVA trial. While the mean reduction...

Functional connectivity between the thalamus and the primary somatosensory cortex in major depressive disorder: a resting-state fMRI study - BMC Psychiatry

Studies have confirmed that the thalamus and the primary somatosensory cortex (SI) are associated with cognitive function. These two brain regions are closely related in structure and function. The interactions between SI and the thalamus are of crucial significance for the cognitive process. Patients with major depressive disorder (MDD) have significant cognitive impairment. Based on these observations, we used resting-state functional magnetic…

Biophysical modeling of high field diffusion MRI demonstrates micro-structural aberration in chronic mild stress rat brain

Depression is one of the leading causes of disability worldwide. Immense heterogeneity in symptoms of depression causes difficulty in diagnosis, and t…

Biological aging acceleration in major depressive disorder: a multi-omics, multi-modal analyses

Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. Using data from two population cohorts (UK Biobank and Finnish Twin Cohort), we evaluate the relationship between systemic and organ-specific proteomic ...